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UOA 12B - Allied Health Professions and Studies: Biomedical Sciences

Manchester Metropolitan University

RA1, RA2 and RA5c: Staff and output details and Category C staff circumstances

 

Ahmed, N - Category : A

Research Groups:

1 - Growth, Disuse and Ageing

RA2 - Research outputs:

Number of outputs: 4

Output number: 1 of 4

Title Comparison of Protective Effects of Aspirin, D-Penicillamine and Vitamin E Against High Glucose-Mediated Toxicity in Cultured Endothelial Cells
Output type: Journal article
Journal title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Month/year of publication: May 2006
Pagination: 551-557
Volume: 1762 (5)
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2006.02.004 ?
Research group: 1 - Growth, Disuse and Ageing
Co-authors: J Zhang, Mark Anthony Slevin, Y Duraisamy
Number of additional co-authors: 2
Other relevant details: We have compared three compounds, which act by different mechanisms, to assess their ability to protect cells against the harmful effects of high glucose and sugar-modified proteins as occurs in diabetes. Our studies showed that vitamin E with combined anti-glycation and antioxidant properties was the most effective.

Output number: 2 of 4

Title Aged Garlic Extract and S-Allyl Cysteine Prevent Formation of Advanced Glycation Endproducts
Output type: Journal article
Journal title: European Journal of Pharmacology
Month/year of publication: April 2007
Pagination: 32-38
Volume: 561 (1-3)
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2007.01.041 ?
Research group: 1 - Growth, Disuse and Ageing
Co-authors: M Pischetsrieder, M S Ahmad
Other relevant details: This study describes for the first time the ability of aged garlic and its key component S-allyl cysteine to protect proteins against sugar-induced damage and may be of value in diabetes. This article was ranked amongst the Top 25 Hottest articles by Science Direct for this journal following its publication.

Output number: 3 of 4

Title Aminosalicylic Acid Reduces the Antiproliferative Effect of Hyperglycaemia, Advanced Glycation Endproducts and Glycated Basic Fibroblast Growth Factor in Cultured Bovine Aortic Endothelial Cells: Comparison with Aminoguanidine
Output type: Journal article
Journal title: Molecular and Cellular Biochemistry
Month/year of publication: April 2003
Pagination: 143-153
Volume: 246 (1-2)
ISSN: 1573-4919
DOI: 10.1023/A:1023470921116 ?
Research group: 1 - Growth, Disuse and Ageing
Co-authors: John Joseph Gaffney, Mark Anthony Slevin, Y Duraisamy
Number of additional co-authors: 2
Other relevant details: We have demonstrated for the first time that aminosalicylic acid can protect cells against the harmful effects of high glucose and sugar-modified proteins. It also preserves the biological activity of basic fibroblast growth factor exposed to high glucose and is more effective than the established anti-glycation drug aminoguanidine.

Output number: 4 of 4

Title Effect of Glycation on Basic Fibroblast Growth Factor Induced Angiogenesis and Activation of Associated Signal Transduction Pathways in Vascular Endothelial Cells: Possible Relevence to Wound Healing in Diabetes
Output type: Journal article
Journal title: Angiogenesis
Month/year of publication: December 2001
Pagination: 277-288
Volume: 4 (4)
ISSN: 1573-7209
URL: Original article on web ?
DOI: 10.1023/A:1016068917266 ?
Research group: 1 - Growth, Disuse and Ageing
Co-authors: Mark Anthony Slevin, N Smith, Y Duraisamy
Number of additional co-authors: 4
Other relevant details: This paper describes the in vitro glycation of basic fibroblast growth factor (FGF) and how this reduces its biological activity with regard to angiogenesis. Glycated FGF has reduced binding to the tyrosine kinase receptor, which we describe for the first time, and this may explain delayed wound healing in diabetes.