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UOA 12 - Allied Health Professions and Studies

Sheffield Hallam University

RA1, RA2 and RA5c: Staff and output details and Category C staff circumstances

 

Abell, BM - Category : A

Research Groups:

B - Biomedical Science

RA2 - Research outputs:

Number of outputs: 4

Output number: 1 of 4

Title Signal recognition particle mediates post-translational targeting in eukaryotes
Output type: Journal article
Journal title: EMBO Journal
Month/year of publication: July 2004
Pagination: 2755-2764
Volume: 23
ISSN: 1460-2075
DOI: 10.1038/sj.emboj.7600281 ?
Research group: B - Biomedical Science
Co-authors: High S, Pool MR, Sinning I
Number of additional co-authors: 1
Other relevant details: SRP was believed to act solely in a cotranslational mode. This research uses tail-anchored proteins to demonstrate a posttranslational mode of action. SRP was the first cytosolic targeting factor identified in tail-anchored protein targeting and opened this field of study. Abell designed and performed the majority of the experiments.

Output number: 2 of 4

Title

Membrane topology and sequence requirements for oil body targeting of oleosin

Output type: Journal article
Journal title: The Plant Journal
Month/year of publication: February 2004
Pagination: 461-470
Volume: 37 (4)
ISSN: 09607412
DOI: 10.1111/j.1365-313X.2003.01988.x ?
Research group: B - Biomedical Science
Co-authors: Hahn M, Holbrook LA, Moloney MM
Other relevant details: Links between topology of oleosin protein in a membrane, and its subsequent trafficking to oil bodies, are analysed in plants. Findings have potential for exploitation in biotechnological applications using oil bodies to accumulate recombinant proteins. Abell designed and performed the majority of the experiments.

Output number: 3 of 4

Title

Post-translational integration of tail-anchored proteins is facilitated by defined molecular chaperones

Output type: Journal article
Journal title: Journal of Cell Science
Month/year of publication: April 2007
Pagination: 1743-1751
Volume: 120
ISSN: 1477-9137
DOI: 10.1242/jcs.002410 ?
Research group: B - Biomedical Science
Co-authors: High S, Rabu C, Young JC
Number of additional co-authors: 1
Other relevant details: The identification of molecular chaperones Hsc70 and Hsp40 provides a long-sought explanation for the dependence of tail-anchored protein targeting on ATP. It allows tail-anchored proteins to be used as a model system to analyse universal features of posttranslational protein targeting. Abell designed and performed the majority of the experiments.

Output number: 4 of 4

Title

Tail-anchored and signal-anchored proteins utilise overlapping pathways during membrane insertion

Output type: Journal article
Journal title: Journal of Biological Chemistry
Month/year of publication: February 2003
Pagination: 5669-5678
Volume: 278(8)
ISSN: 1083-351X
DOI: 10.1074/jbc.M209968200 ?
Research group: B - Biomedical Science
Co-authors: High S, Jung M, Zimmerman R
Number of additional co-authors: 3
Other relevant details: Components responsible for insertion of tail-anchored proteins at the ER proved elusive for many years. We provide strong evidence that classical translocation machinery plays a major role in this process, thereby initiating understanding of the whole targeting pathway in molecular detail. Abell designed and performed the majority of the experiments.