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UOA 25 - General Engineering and Mineral & Mining Engineering

University of Strathclyde

RA1, RA2 and RA5c: Staff and output details and Category C staff circumstances

 

Black, RA - Category : A

Research Groups:

C - Cell, Tissue and Organ Engineering

RA2 - Research outputs:

Number of outputs: 4

Output number: 1 of 4

Title Anatomical flow phantoms of the nonplanar carotid bifurcation, Part I: Computer-aided Design and Fabrication.
Output type: Journal article
Journal title: Ultrasound in Medicine and Biology
Month/year of publication: January 2007
Pagination: 296-302
Volume: 33
ISSN: 0301-5629
DOI: 10.1016/j.ultrasmedbio.2006.08.003 ?
Interdisciplinary output: Yes
Research group: C - Cell, Tissue and Organ Engineering
Co-authors: Connell, M, Hoskins, P R, Meagher, S
Number of additional co-authors: 6
Other relevant details: First of two papers in which state-of-the-art image processing tools for segmentation of medical images and methodology for the fabrication of anatomically accurate flow phantoms are described for the purpose of validating clinical indices of disease based on Doppler ultrasound velocity data; tools that will help researchers establish the extent to which haemodynamic factors influence the onset and progression of vascular diseases and ensure better diagnosis and treatment Contribution: Supervisor of first author, with direct input into the design and execution of this study. Corresponding author with responsibility for the writing and submission of final draft of paper.

Output number: 2 of 4

Title Oxygen transport and cell viability in an annular flow bioreactor: comparison of laminar Couette and Taylor-vortex flow regimes
Output type: Journal article
Journal title: Biotechnology and Bioengineering
Month/year of publication: March 2005
Pagination: 766-774
Volume: 89
ISSN: 1097-0290
DOI: 10.1002/bit.20361 ?
Research group: C - Cell, Tissue and Organ Engineering
Co-authors: Curran, S
Other relevant details: Experimental study that reports for the first time how laminar Taylor-vortex flow regimes and scaling effects may be exploited in the cultivation of cells in suspension to enhance mass transport in rotating wall vessel bioreactors without loss of viability through shear-induced damage, findings that will have important implications for the commercial expansion of mammalian cells in the biotechnology, bioprocess and Tissue Engineering sectors. Contribution: Senior author (PI) and PhD supervisor of first author, with direct input into the design and execution of this study. Corresponding author with responsibility for submission of final draft of paper.

Output number: 3 of 4

Title Distinct NF-kappa B regulation by shear stress through ras-dependent I kappa B alpha oscillations - Real-time analysis of flow-mediated activation in live cells
Output type: Journal article
Journal title: Circulation Research
Month/year of publication: January 2005
Pagination: 626-634
Volume: 96
ISSN: 1524-4571
DOI: 10.1161/01.RES.0000160435.83210.95 ?
Interdisciplinary output: Yes
Research group: C - Cell, Tissue and Organ Engineering
Co-authors: Ganguli, R, Palmer, I, Persson, L
Number of additional co-authors: 2
Other relevant details: Elucidates specific molecular pathways underlying flow-mediated activation of NF-kappaB, a transcription factor central to inflammation and atherosclerosis; reports, for the first time, mechanisms of NF-kappaB control at the molecular level likely to have fundamental impact on the development of distinct shear-stress induced vascular phenotypes in relation to cardiovascular disease. Contribution: Paper was principal output of MRC Discipline Hopping award to RAB and EQ. Devised and built experimental flow chamber apparatus used in this study, and trained first author in its use. Contributed to the design of the study (haemodynamic aspects) and to final draft of paper.

Output number: 4 of 4

Title α2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an α2β1 integrin dependent mechanism: an in vitro and in vivo study
Output type: Journal article
Journal title: Circulation
Month/year of publication: January 2006
Pagination: 820-829
Volume: 114
ISSN: 1524-4539
DOI: 10.1161/CIRCULATIONAHA.106.635292 ?
Research group: C - Cell, Tissue and Organ Engineering
Co-authors: Canfield, A E, Humphries, M J, Kielty, C M
Number of additional co-authors: 4
Other relevant details: Study originating from internationally-rated group reports an 18-fold higher affinity over fibronectin of alpha2(VIII) collagen homotrimers as attachment factor for endothelial cells when exposed to shear stress; discovery represent a major advance toward single-stage endothelialisation of prosthetic vascular grafts, with important implications for the development of the next generation of Tissue Engineered blood vessels and regenerative medicine approaches to bypass surgery and cardiovascular implants in general. Contribution: Principal Investigator on major collaborative research grant between the Universities of Manchester and Liverpool (UK Centre for Tissue Engineering), with responsibility for the design, fabrication and characterisation of the polyurethane vascular grafts used.