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UOA 18 - Chemistry

RA1, RA2 and RA5c: Staff and output details and Category C staff circumstances

 

Blindauer, C A - Category : A

RA2 - Research outputs:

Number of outputs: 4

Output number: 1 of 4

Title

Toward a property/function relationship for metallothioneins: Histidine coordination and unusual cluster composition in a zinc metallothionein from plants. 

Output type: Journal article
Journal title: Proteins: Structure, Function and Bioinformatics
Month/year of publication: June 2007
Pagination: 922-935
Volume: 68(4)
ISSN: 08873585
DOI: 10.1002/prot.21463 ?
Interdisciplinary output: Yes
Co-authors: Leszczyszyn O I, Schmid R
Other relevant details: Results confirming the hypothesis put forward in Blindauer’s proposal to the Royal Society for successful Olga Kennard Fellowship that plant metallothioneins have unprecedented and, as yet, unpredictable properties. Blindauer conceived and supervised the project, Schmid contributed bioinformatics analyses.

Output number: 2 of 4

Title

Histidine ligands in bacterial metallothionein enhance cluster stability

Output type: Journal article
Journal title: Journal of Biological Inorganic Chemistry
Month/year of publication: March 2007
Pagination: 393-405
Volume: 12(3)
ISSN: 09498257
DOI: 10.1007/s00775-006-0196-4 ?
Co-authors: Campopiano D J, Razi M T, Sadler P J
Other relevant details: Work supported by Wellcome Trust Project Grant (06/2003-07/2005; grant no. 070481), on which Blindauer was co-applicant, providing fundamental insights into the impact of zinc-binding histidine residues on structure, dynamics, and metal-ion affinity in a model protein. Blindauer supervised project, carried out experimental work and wrote the manuscript.

Output number: 3 of 4

Title

Inert Site in a Protein Zinc Cluster : Isotope Exchange by High Resolution Mass Spectrometry

Output type: Journal article
Journal title: Journal of the American Chemical Society
Month/year of publication: March 2003
Pagination: 3226-3227
Volume: 125(11)
ISSN: 00027863
DOI: 10.1021/ja0284409 ?
Interdisciplinary output: Yes
Co-authors: Harrison M D, Keiper S E, Polfer N C
Number of additional co-authors: 3
Other relevant details: A widely applicable approach that reveals the unusual dynamics of a zinc finger/metallothionein protein. As a postdoc, Blindauer oversaw the project involving three groups, conceived experimental design, carried out part of the experimental work, and wrote the manuscript. Newcastle supplied plasmids, Edinburgh SIRCAMS provided MS expertise.

Output number: 4 of 4

Title

A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity

Output type: Journal article
Journal title: Proceedings of the National Academy of Sciences of the United States of America
Month/year of publication: August 2001
Pagination: 9593-9598
Volume: 98(17)
ISSN: 00278424
DOI: 10.1073/pnas.171120098 ?
Interdisciplinary output: Yes
Co-authors: Harrison M D, Parkinson J A, Robinson A K
Number of additional co-authors: 3
Other relevant details: Work by Blindauer (experimental and manuscript preparation) as postdoc in the Sadler group, partly supported by Swiss National Science Foundation and Novartis Foundation fellowships and leading to funding from the EU (Marie Curie Fellowship, 11/2000-10/2002; HPMF-CT-2000-00491), the Wellcome Trust (06/2003-06/2005; grant no. 070481), and the Royal Society (10/2004-).