You are in: Submissions > Select institution > Imperial College London > UOA 3 - Infection and Immunology > RA1, RA2 and RA5c

Imperial College London

UOA 3 - Infection and Immunology

RA1, RA2 and RA5c: Staff and output details and Category C staff circumstances

 

Agranoff, DD - Category : A

Research Groups:

B - Bacterial pathogens, fungal biology and parasitology

RA2 - Research outputs:

Number of outputs: 4

Output number: 1 of 4

Title Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum.
Output type: Journal article
Journal title: The Lancet
Month/year of publication: September 2006
Pagination: 1012 - 1021
Volume: 368 (9540)
ISSN: 1474-547X
DOI: 10.1016/S0140-6736(06)69342-2 ?
Research group: B - Bacterial pathogens, fungal biology and parasitology
Co-authors: Fernandez-Reyes, D, Papadopoulos, MC, Rojas, SA
Number of additional co-authors: 8
Other relevant details: Machine-learning used to identify patterns of mass spectral peaks in serum that distinguish between TB patients and controls with overlapping clinical features. Lead to a patent and demonstrates the great potential of proteomic fingerprinting as highly sensitive diagnostic method identifying characteristic changes in serum proteins associated with pulmonary tuberculosis.(First author).

Output number: 2 of 4

Title A novel and accurate diagnostic test for human African trypanosomiasis.
Output type: Journal article
Journal title: The Lancet
Month/year of publication: April 2004
Pagination: 1358 - 1363
Volume: 363 (9418)
ISSN: 1474-547X
DOI: 10.1016/S0140-6736(04)16046-7 ?
Research group: B - Bacterial pathogens, fungal biology and parasitology
Co-authors: Abel, PM, Papadopoulos, MC, Stich, A
Number of additional co-authors: 7
Other relevant details: Demonstrates proof of principle that a novel conceptual approach to diagnostics can be applied successfully to diagnosis of an infectious disease (trypanosomiasis), lays groundwork for development of highly sensitive tests for other important infections based on characteristic changes in serum proteins. Agranoff conceived and designed the study, co-wrote paper.

Output number: 3 of 4

Title The Nramp orthologue of Cryptococcus neoformans is a pH-dependent transporter of manganese, iron, cobalt and nickel.
Output type: Journal article
Journal title: Biochemical Journal
Month/year of publication: January 2005
Pagination: 225 - 232
Volume: 385 (1)
ISSN: 1470-8728
DOI: 10.1042/BJ20040836 ?
Research group: B - Bacterial pathogens, fungal biology and parasitology
Co-authors: Collins, L, Harrison, T, Kehres, D
Number of additional co-authors: 2
Other relevant details: This functional characterisation of an important family of divalent cation transporters for the first time in a fungal pathogen, reveals important similarities as well as differences between the Cryptococcal and Saccharomyces orthologues and enlarges our understanding of the ubiquity and the heterogeneity of this family of transporters.(First author).

Output number: 4 of 4

Title Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria.
Output type: Journal article
Journal title: Antimicrobial Agents and Chemotherapy
Month/year of publication: February 2001
Pagination: 509 - 516
Volume: 45 (2)
ISSN: 0066-4804
DOI: 10.1128/AAC.45.2.509-516.2001 ?
Research group: B - Bacterial pathogens, fungal biology and parasitology
Co-authors: Agbenyega, T, Krishna, S, Planche, T
Number of additional co-authors: 7
Other relevant details: This detailed pharmacokinetic study provided the scientific basis for the initiation of population based trials of a novel anti-malarial formulation in children with mild-moderate malaria in Africa. Agranoff was a key contributor to study design, recruited patients, collected samples and contributed to data analysis and paper writing.